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What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry
Friday, 11 May, 10:00 » 12:00
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Ústav organické chemie a biochemie AV ČR zve na přednášku, kterou přednese Prof. Gerhard Klebe:
What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry
Small-molecule drug discovery involves the optimization of various physicochemical properties of a ligand, particularly the binding affinity for its target protein(s). In recent years, there has been growing interest in using thermodynamic profiling of protein-ligand interactions in order to select and optimize those ligands that look most promising to become a drug candidate with desirable physicochemical properties.
What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry
Small-molecule drug discovery involves the optimization of various physicochemical properties of a ligand, particularly the binding affinity for its target protein(s). In recent years, there has been growing interest in using thermodynamic profiling of protein-ligand interactions in order to select and optimize those ligands that look most promising to become a drug candidate with desirable physicochemical properties.
Přednáškový sál, 2. patro - Flemingovo nám. 2, Praha 6 – Dejvice